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Most patients (provided they are lean) will be able to put a subcutaneous needle VERY close to the muscle (if not inside) depending on the site they use for the injection
This schedule uses the largest practical dilution (3.0 mL) to keep per-injection units well above 5 for better accuracy
The most abnormal thing here is the advisory committee overruling FDA scientists in a wholesale fashion, says Howard Sklamberg, an Arnold & Porter Life Sciences & Healthcare Regulatory partner and former deputy commissioner for Global Regulatory Operations and Policy at the FDA
Santos et al
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